The article traces the historical and medicinal significance of chamomile. Initially, chamomile was modestly referenced by early Greek physicians, such as Hippocrates and Theophrastus, who described it primarily for its gynecological and diuretic benefits. Over time, prominent figures like Asclepiades and Dioscorides expanded its medicinal uses, particularly in gynecology, digestive issues, and bladder treatments. Later, Galen analyzed chamomile’s anti-inflammatory effects, comparing it with other plants. In medieval Europe, chamomile was used in remedies for jaundice, fever, and snake bites, while in the Islamic world, Avicenna detailed its application for various ailments, including digestive, respiratory, and gynecological conditions. Chamomile’s journey through history was not only marked by its medicinal benefits but also by its role in folklore and rituals, as seen in charms and amulets. It is also popular for its cosmetic use, particularly as a natural hair lightener. Despite its humble beginnings, chamomile became an important plant in both ancient and medieval medicinal traditions.